Nevertheless, Gies resisted being made a character study of heroism for the young.
"I don't want to be considered a hero," she said in a 1997 online chat with schoolchildren.
"Imagine young people would grow up with the feeling that you have to be a hero to do your human duty. I am afraid nobody would ever help other people, because who is a hero? I was not. I was just an ordinary housewife and secretary."
Born Hermine Santrouschitz on Feb. 15, 1909 in Vienna, Gies moved to Amsterdam in 1922 to escape food shortages in Austria. She lived with a host family who gave her the nickname Miep.
In 1933, Gies took a job as an office assistant in the spice business of Otto Frank. After refusing to join a Nazi organization in 1941, she avoided deportation to Austria by marrying her Dutch boyfriend, Jan Gies.
As the Nazis ramped up their arrests and deportations of Dutch Jews, Otto Frank asked Gies in July 1942 to help hide his family in the annex above the company's canal-side warehouse on Prinsengracht 263 and to bring them food and supplies.
"I answered, 'Yes, of course.' It seemed perfectly natural to me. I could help these people. They were powerless, they didn't know where to turn," she said years later.
Jan and Miep Gies worked with four other employees in the firm to sustain the Franks and four other Jews sharing the annex. Jan secured extra food ration cards from the underground resistance. Miep cycled around the city, alternating grocers to ward off suspicions from this highly dangerous activity.
In her e-mail to the AP last February, Gies remembered her husband, who died in 1993, as one of Holland's unsung war heroes. "He was a resistance man who said nothing but did a lot. During the war he refused to say anything about his work, only that he might not come back one night. People like him existed in thousands but were never heard," she wrote.
Touched by Anne's precocious intelligence and loneliness, Miep also brought Anne books and newspapers while remembering everybody's birthdays and special days with gifts.
"It seems as if we are never far from Miep's thoughts," Anne wrote.
In her own book, "Anne Frank Remembered," Gies recalled being in the office when the German police, acting on a tip that historians have failed to trace, raided the hide-out in August 1944.
A policeman opened the door to the main office and pointed a revolver at the three employees, telling them to sit quietly. "Bep, we've had it," Gies whispered to Bep Voskuijl.
After the arrests, she went to the police station to offer a bribe for the Franks' release, but it was too late. On Aug. 8, they were sent to Westerbork, a concentration camp in eastern Holland from where they were later packed into cattle cars and deported to Auschwitz. A few months later, Anne and her sister Margot were transported to Bergen-Belsen.
Two of the helpers, Victor Kugler and Johannes Kleiman, were sent to labor camps, but survived the war.
Around 140,000 Jews lived in the Netherlands before the 1940-45 Nazi occupation. Of those, 107,000 were deported to Germany and only 5,200 survived. Some 24,000 Jews went into hiding, of which 8,000 were hunted down or turned in.
After the war, Otto Frank returned to Amsterdam and lived with the Gies family until he remarried in 1952. Miep worked for him as he compiled the diary, then devoted herself to talking about the diary and answering piles of letters with questions from around the world.
After Otto Frank's death in 1980, Gies continued to campaign against Holocaust-deniers and to refute allegations that the diary was a forgery.
She suffered a stroke in 1997 which slightly affected her speech, but she remained generally in good health as she approached her 100th birthday.
Her son Paul Gies said last year she was still receiving "a sizable amount of mail" which she handled with the help of a family friend. She spent her days at the apartment where she lived since 2000 reading two daily newspapers and following television news and talk shows.
Her husband died in 1993. She is survived by her son and three grandchildren.